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What Is Lymphedema?
Lymphedema is swelling of a body part, most often affecting the extremities, like the arms or legs. It can affect multiple areas of the body, such as the upper extremities, lower extremities, head, neck, chest and genitals. Lymphedema is caused by an abnormal accumulation of lymphatic fluid. Although it’s a progressive chronic condition, it can usually be controlled by medical attention and quality care.
Lymphedema symptoms can range from mild to severe:
- Swelling
- A feeling of heaviness or tightness
- Hardening and thickening of the skin
- Recurring infections
- Restricted range of motion
Primary lymphedema cases occur without any obvious cause and may be present at birth, in adolescence or develop after age 35. Primary lymphedema is considered rare, occurs more in females and is most widely experienced in the legs.
Secondary lymphedema, the most common form of the condition, is caused by injury, scarring or excision of the lymph nodes. It usually occurs because of previous radiation exposure, or from surgery on the lymph nodes. Occasionally, trauma or chronic infections of the lymphatic system can cause secondary lymphedema.
How Does Lymphedema Occur With Breast Cancer?
The lymphatic collectors of the arm drain in most patients through the lymph nodes of the axilla or armpit. The lymphatic collectors of the breast also drain into the same lymph nodes. In breast cancer treatment, the axillary nodes are sampled to determine if the cancer has spread beyond the breast. This is called a sentinel node biopsy.
Sometimes, if there is cancer in the sentinel lymph node, most of the axillary nodes must be removed to prevent the cancer from coming back into the axilla (a procedure called an axillary lymph node dissection, or ALND).
The risk of developing lymphedema after a sentinel lymph node biopsy is small but can still occur. The risk of developing lymphedema after most axillary nodes are removed is much greater at about 20 to 30% of cases, especially if the axilla is treated with postoperative radiation therapy.
What are the Risk Factors for Developing Lymphedema with Breast Cancer?
- Axillary lymph nodes dissection (ALND)
- Axillary radiation
- Developing a postoperative hematoma (blood clot in the wound)
- Developing a postoperative infection
- Having a BMI greater than 30
- Having a total mastectomy
- Receiving Taxane chemotherapy
- Removing more than six nodes when performing a sentinel lymph node biopsy
Lymphedema Treatments
- What Do I Do if I Develop Lymphedema?
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At AdventHealth, we have a surveillance program for cancer patients that will follow you closely after you’ve started your cancer treatment. We’ll measure your limb volumes over time and use bioimpedance to determine if you are developing an early form of lymphedema. If you do develop lymphedema, you’ll be referred to our lymphatic therapist, who will begin lymphedema physical therapy immediately. Our therapists are located on multiple campuses for your convenience.
Lymphatic physical therapy consists of performing complete decongestive therapy (CDT), which includes:
- Manual Lymphatic Drainage (MLD)
This technique empties and decompresses obstructed lymph vessels by rerouting the fluid into body segments where the lymph system functions properly. This therapy facilitates the unhindered flow of lymph fluid into the venous circulation, which allows the limb to return to normal or near normal size.
- Bandaging and Compression
Bandaging of the affected limb follows each manual lymph drainage session. This is important as it prevents the affected limb from refilling with stagnant lymph. An external compression is usually a custom-fitted compression garment that applies pressure on the skin and tissues to prevent the lymphatic fluid from reaccumulating.
- Remedial Exercises and Elevation
Corrective exercises with bandages in place are prescribed for every patient. This step activates the muscle groups and joints of the swollen limb. It results in increased lymph flow and further reduces limb swelling over time.
- Hygiene and Topical Skin Products
Meticulous hygienic care with or without antibiotics is essential. This treatment aims to eliminate bacterial and fungal growth, which can lead to repeated attacks of cellulitis and lymphangitis.
- Pneumatic Pumps
Manual lymph drainage is preferred to mechanical pneumatic pumping because it doesn’t damage remaining lymphatic vessels or their delicate valves.
- What Happens if I Have Lymphedema and I Don’t Get Treated?
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Once you develop lymphedema, the swelling will worsen over time unless it is controlled with CDT. Once significant swelling sets into the lymphatic fluid in the tissues, it causes inflammation of the interstitial space, leading to the accumulation of fat cells and scarring, which is referred to as lipo fibrosis. Once you develop this condition, it becomes very difficult to treat the involved area. You’d also be at risk of developing a serious infection called cellulitis that may require hospitalization to receive intravenous antibiotics.
Testing We Offer to Diagnose Lymphedema
- Bioimpedance Spectroscopy
- Indocyanine Green (ICG) Testing
- MR Lymphangiogram
- Nuclear Medicine Lymphoscintigraphy
- Ultra-High Frequency Ultrasound
- Venous Ultrasound
Lymphedema Surgery Options
- Immediate Lymphatic Reconstructions (ILR)
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This prophylactic operation is performed at the time of a mastectomy with lymph node removal or within 7 to 10 days of a mastectomy with lymph node removal. The goal of an ILR is to prevent lymphedema from occurring. In this surgery, the lymphatic channels or collectors draining the arm are identified in the armpit using a variety of special dyes. Once the nodes are removed, these channels normally scar down, leading to lymphatic flow blockage and possible lymphatic fluid accumulation, and lymphedema. Instead of allowing them to scar down, these collectors are sewn directly into an adjacent vein, allowing the lymph fluid to flow directly from the collectors into the vein, which significantly decreases the risk of developing lymphedema after an axillary lymph node dissection.
- Vascularized Lymph Node Transfer (VLNT)
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If you develop lymphedema and are controlling your symptoms with CDT, we can help improve your symptoms by performing a vascularized lymph node transfer. Your surgeon will remove four to six lymph nodes from another part of your body and transfer them to the affected area. The lymph node packet is attached to an artery and a vein to provide nutrition and oxygen to the “transplanted” nodes. Once your body heals, the lymph nodes will begin forming new lymph channels that will help drain the excess lymphatic fluid accumulated in the involved area. Using custom compression garments is still important, but you may not have to wear them as frequently throughout the day.
- Liposuction Debulking
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If you develop more advanced lymphedema, the tissues swell due to the accumulation of lymphatic fluid as well as from the accumulation of fat cells and scar tissue. This lipo fibrosis causes further enlargement. Your surgeon can help reduce the volume by removing the fat and scar layer with liposuction. This is often called lipo debulking, or suction-assisted protein lipectomy (SAPL). This operation is usually performed six months after the VLNT procedure if necessary.
- Lymphovenous Bypass
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A lymphovenous bypass surgery is performed to target and bypass an area of blockage within a lymphatic vessel. Special dyes are injected prior to surgery to identify the lymphatic vessels. A section of your lymphatic vessel that isn’t blocked is connected to a nearby vein to allow lymphatic fluid to drain, which can help improve your lymphedema symptoms. To be considered as a candidate, you will be recommended to undergo Indocyanine Green (ICG) mapping to determine if you have adequate lymphatic vessels and nearby veins to use for this procedure.
Your Lymphedema Experts
LEARN Recognition
AdventHealth is recognized as a LEARN Comprehensive Network Center of Excellence in Lymphatic Disease.